https://medznow.com/oxycodone-vs-hydromorphone/
Oxycodone and hydromorphone are both opioid analgesics used for moderate to severe pain, but they differ in potency, dosing, and side-effect profiles. Hydromorphone is significantly more potent—about 4–7 times stronger than oxycodone—so smaller doses achieve similar pain relief. Oxycodone is available in immediate- and extended-release forms, often used for chronic pain, while hydromorphone is typically reserved for more severe or breakthrough pain. Hydromorphone may cause more sedation, while oxycodone is more commonly associated with nausea. Both carry risks of dependence, respiratory depression, and misuse, so they must be used under close medical supervision.
