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Gabapentin and Tramadol are basically used to treat different types of pain, and both are very effective for managing pain. Tramadol is a scheduled IV controlled substance and synthetic opioid prescribed to manage moderate to severe pain, chronic pain, and anxiety. Gabapentin is a prescription drug that is primarily used to treat nerve pain, and it works by modulating nerve signals in the brain. Gabapentin is an addictive non-habituating drug, and this may cause drowsiness and coordination issues. Tramadol is a habit-forming because it is used for a long time period, which can cause constipation and nausea.