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Codeine and hydrocodone are both prescription opioid medications that can be used to treat similar conditions, but there are some important differences between each drug. Hydrocodone belongs to a class of pharmaceuticals known as opiate analgesics, primarily prescribed for managing moderate to severe pain. Codeine is another opiate analgesic and antitussive, typically prescribed to manage mild to moderate pain and cough symptoms. When codeine is used for pain relief, it changes how your brain and nervous system deal with pain.