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Clonidine and Adderall are both prescribed medications to manage ADHD. Clonidine is prescribed to treat anxiety, alcohol withdrawl, and high blood pressure. Adderall is prescribed to treat narcolepsy, and that also classified as a CNS stimulant drug. The brain receives increased dopamine and norepinephrine levels from Adderall, which enhances focus, attention, and alertness, thus making it the primary treatment for ADHD. The non-stimulant Clonidine functions by activating alpha-2 adrenergic receptors to calm the brain while decreasing hyperactivity and impulsivity. Adderall stimulates the brain to improve attention and energy, while Clonidine calms the nervous system to reduce hyperactivity and aid sleep. Clonidine causes low blood pressure, confusion, and dry mouth, and also Adderall causes weight loss and headache.