Oxycodone and tramadol are prescription opioid medications used to manage moderate to severe pain, but they differ in strength, risks, and effects. Oxycodone is a stronger opioid and is often prescribed for severe or chronic pain, such as after surgery or injury. Tramadol is considered weaker and is sometimes used for moderate pain. Oxycodone carries a higher risk of dependence, misuse, and side effects like respiratory depression. Tramadol has a lower opioid effect but can still cause dependence and may affect mood or cause seizures in some cases. Choosing between them depends on pain severity and medical guidance.