Adderall and caffeine both stimulate the central nervous system, increasing alertness and energy. However, combining them can intensify side effects such as anxiety, insomnia, increased heart rate, and high blood pressure. This combination may also heighten the risk of jitteriness, restlessness, and heart palpitations. For individuals with heart conditions or anxiety disorders, the risks are greater. While small amounts of caffeine may be tolerated, it’s best to limit intake and consult a healthcare provider before mixing the two. Using both together can strain the body and reduce Adderall’s effectiveness in managing ADHD symptoms.